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  Angiogenesis is a broadly known four-stage course of of latest blood vessel formation that happens in wholesome people (e.g., during the menstrual cycle or muscle growth) but additionally in immune diseases [106]. Although the proper improvement of the vascular network allows fuel trade and transport of metabolic products in the organs, angiogenesis additionally occurs in lots of pathological conditions [107]. This additionally applies to cancer, because the formation of blood vessels throughout carcinogenesis permits oxygen supply to the tumor and enhances its proliferation, diffusion, and metastasis [108,109,110]. Importantly, it has been reported that the pentadecapeptide impacts signaling of one of many crucial angiogenic components, the vascular endothelial progress factor and its receptors (VEGFR). Indeed, BPC 157 elevated expression of the VEGFR-2 receptor in rats with hind limb ischemia and in endothelial cell cultures [14,111]. However, the VEGF family and its receptors, including VEGFR, have been found to be expressed in about half of the human cancers studied, such as ovarian cancer, melanoma, thyroid cancer, and more [111,112,113,114]. BPC-157 works by accelerating the healing strategy of damaged tissues, together with these damaged by most cancers.
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